GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | VEGFA | increases expression | EXP | | 6480464 | CTD | Arsenic results in increased expression of VEGFA protein | PMID:25559853 | VEGFA | multiple interactions | EXP | | 6480464 | CTD | [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA; [Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of VEGFA mRNA; CAT protein inhibits the reaction [[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA]; cucurbitacin I inhibits the reaction [Arsenic results in increased expression of VEGFA protein]; diphenyleneiodonium inhibits the reaction [[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA]; STAT3 protein affects the reaction [Arsenic results in increased expression of VEGFA protein]; VEGFA gene SNP affects the susceptibility to [Tobacco Smoke Pollution co-treated with Arsenic] | PMID:21687637 PMID:23009795 PMID:25559853 | VEGFA | multiple interactions | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of VEGFA protein | PMID:33904385 | | ||||||||||||||||||||||
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