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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2624
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fn1
Name: fibronectin 1
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fn1increases expressionEXP 6480464CTDArsenic results in increased expression of FN1 mRNAPMID:24348802
Fn1multiple interactionsEXP 6480464CTDGrape Seed Extract inhibits the reaction [Arsenic results in increased expression of FN1 mRNA]PMID:24348802
Fn1multiple interactionsISOFn1 (Mus musculus)6480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in increased expression of FN1 mRNA; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in increased expression of FN1 protein; [sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Dietary Fats results in increased expression of FN1 protein]; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of FN1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of FN1 proteinPMID:31238026
Fn1multiple interactionsISOFN1 (Homo sapiens)6480464CTD[Arsenic co-treated with Estradiol] results in increased expression of FN1 proteinPMID:33047385
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