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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593284
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa1a
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa1adecreases expressionISOHspa1a (Mus musculus)6480464CTDArsenic results in decreased expression of HSPA1A mRNAPMID:19654921
Hspa1aincreases expressionISOHspa1a (Mus musculus)6480464CTDArsenic results in increased expression of HSPA1A mRNAPMID:22956628
Hspa1amultiple interactionsISOHSPA1A (Homo sapiens)6480464CTD[sodium arsenate results in increased abundance of Arsenic] which results in increased expression of HSPA1A mRNAPMID:32525701
Hspa1amultiple interactionsISOHspa1a (Mus musculus)6480464CTD[HSPA1A protein co-treated with HSPA1B protein] results in decreased susceptibility to ArsenicPMID:9820195
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