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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350637
Species: Homo sapiens
RGD Object: Gene
Symbol: TOP2B
Name: DNA topoisomerase II beta
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TOP2Bdecreases expressionEXP 6480464CTDArsenic results in decreased expression of TOP2B mRNA, Arsenic results in decreased expression of TOP2B protein

PMID:21332098
TOP2Bmultiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B mRNA], Curcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B protein]

PMID:21332098
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.