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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346464
Species: Homo sapiens
RGD Object: Gene
Symbol: H2AX
Name: H2A.X variant histone
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2AXincreases expressionEXP 6480464CTDArsenic results in increased expression of H2AX mRNA; Arsenic results in increased expression of H2AX proteinPMID:29161537 PMID:31822296 PMID:34998823
H2AXmultiple interactionsEXP 6480464CTD[UNG protein affects the susceptibility to Arsenic] which affects the expression of H2AX protein; APOBEC3B protein affects the reaction [[UNG protein affects the susceptibility to Arsenic] which affects the expression of H2AX protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone affects the reaction [Arsenic results in increased expression of H2AX protein]; FTO protein affects the reaction [Arsenic results in increased expression of H2AX protein]; NFATC3 protein inhibits the reaction [Arsenic results in increased expression of H2AX protein]; YTHDF2 protein affects the reaction [FTO protein affects the reaction [Arsenic results in increased expression of H2AX protein]]PMID:31822296 PMID:34998823
H2AXincreases expressionISOH2ax (Mus musculus)6480464CTDArsenic results in increased expression of H2AX proteinPMID:34998823
H2AXmultiple interactionsISOH2ax (Rattus norvegicus)6480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of H2AX proteinPMID:31542844
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