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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:27539
Term: isatin
Definition: An indoledione that is the 2,3-diketo derivative of indole.
Chemical ID: MESH:D007510
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1amultiple interactionsISORGD:7353416480464CTD[Copper binds to Isatin binds to 2-2-aminoethylpyridine] which results in increased expression of CDKN1A protein [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein]

PMID:17327230
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