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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:27504
Term: mitomycin C
Definition: A mitomycin that has formula C15H18N4O5.
Chemical ID: MESH:D016685
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceEXP 6480464CTDNQO1 protein affects the susceptibility to Mitomycin

PMID:16217747
increases metabolic processingEXP 6480464CTDNQO1 protein results in increased metabolism of Mitomycin

PMID:1701346
increases reductionEXP 6480464CTDNQO1 protein results in increased reduction of Mitomycin

PMID:24552538
increases response to substanceEXP 6480464CTDNQO1 mRNA results in increased susceptibility to Mitomycin, NQO1 protein results in increased susceptibility to Mitomycin

PMID:15239142, PMID:16494910
multiple interactionsEXP 6480464CTD[arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin, [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Mitomycin, [Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Mitomycin, [Oxygen deficiency co-treated with Mitomycin] results in decreased activity of NQO1 protein, [Tetrachlorodibenzodioxin co-treated with Mitomycin co-treated with Oxygen deficiency] affects the activity of NQO1 protein, [Tetrachlorodibenzodioxin co-treated with Mitomycin] results in decreased activity of NQO1 protein, Dicumarol inhibits the reaction [[arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin], Dicumarol inhibits the reaction [NQO1 protein results in increased metabolism of Mitomycin], NQO1 protein results in increased metabolism of and results in increased susceptibility to Mitomycin

PMID:15655414, PMID:16226770, PMID:16494910, PMID:1701346, PMID:9865924
increases metabolic processingISORGD:25036480464CTDNQO1 protein results in increased metabolism of Mitomycin

PMID:1701346
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.