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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:27496
Term: simazine
Definition: A diamino-1,3,5-triazine that is N,N'-diethyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.
Chemical ID: MESH:D012839
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDSimazine binds to ESR1 proteinPMID:8858116
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDSimazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]PMID:8858116
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