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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737005
Species: Homo sapiens
RGD Object: Gene
Symbol: GPX1
Name: glutathione peroxidase 1
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GPX1affects activityISOGpx1 (Rattus norvegicus)6480464CTDFolic Acid affects the activity of GPX1 proteinPMID:16251605
GPX1affects expressionISOGpx1 (Rattus norvegicus)6480464CTDFolic Acid affects the expression of GPX1 proteinPMID:16251605
GPX1multiple interactionsISOGpx1 (Mus musculus)6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GPX1 mRNAPMID:22206623
GPX1multiple interactionsISOGpx1 (Rattus norvegicus)6480464CTD[Vitamin E co-treated with Folic Acid] inhibits the reaction [Hydrogen Peroxide results in decreased activity of GPX1 protein]PMID:28849685
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