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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735618
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3multiple interactionsEXP 6480464CTD[Folic Acid co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of NOS3 protein; Folic Acid inhibits the reaction [cobaltous chloride affects the phosphorylation of NOS3 protein]; Folic Acid inhibits the reaction [Homocysteine results in decreased expression of and results in decreased activity of NOS3 protein]; Folic Acid inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein]PMID:17357445 PMID:26906511 PMID:28624453
NOS3decreases expressionISONos3 (Mus musculus)6480464CTDFolic Acid results in decreased expression of NOS3 proteinPMID:33404076
NOS3multiple interactionsISONos3 (Mus musculus)6480464CTDFolic Acid inhibits the reaction [AGT protein results in decreased expression of NOS3 protein]; Folic Acid inhibits the reaction [Doxorubicin results in decreased phosphorylation of and results in increased glutathionylation of NOS3 protein]; Nicorandil inhibits the reaction [Folic Acid results in decreased expression of NOS3 protein]PMID:24386282 PMID:28608983 PMID:33404076
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