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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735516
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2L1
Name: BCL2 like 1
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2L1multiple interactionsEXP 6480464CTDFolic Acid inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 mRNA]; Folic Acid inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 mRNA]PMID:30581319
BCL2L1decreases expressionISOBcl2l1 (Mus musculus)6480464CTDFolic Acid results in decreased expression of BCL2L1 proteinPMID:16595132
BCL2L1increases expressionISOBcl2l1 (Mus musculus)6480464CTDFolic Acid results in increased expression of BCL2L1 mRNAPMID:25629700
BCL2L1multiple interactionsISOBcl2l1 (Mus musculus)6480464CTDFolic Acid inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with MAPT protein mutant form] results in decreased expression of BCL2L1 protein]; TNF protein affects the reaction [Folic Acid results in decreased expression of BCL2L1 protein]PMID:16595132 PMID:29068127
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