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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62178
Species: Mus musculus
RGD Object: Gene
Symbol: Timp2
Name: tissue inhibitor of metalloproteinase 2
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp2decreases expressionEXP 6480464CTDFolic Acid results in decreased expression of TIMP2 mRNAPMID:25629700
Timp2multiple interactionsEXP 6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TIMP2 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TIMP2 mRNA; Folic Acid inhibits the reaction [AGT protein results in decreased expression of TIMP2 protein]PMID:20938992 PMID:22206623 PMID:24386282
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