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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3830
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hnf1b
Name: HNF1 homeobox B
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hnf1bincreases expressionISOHNF1B (Homo sapiens)6480464CTDFolic Acid deficiency results in increased expression of HNF1B mRNAPMID:28752528
Hnf1bincreases methylationISOHNF1B (Homo sapiens)6480464CTDFolic Acid deficiency results in increased methylation of HNF1B promoterPMID:28752528
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