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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550066
Species: Mus musculus
RGD Object: Gene
Symbol: Rfc1
Name: replication factor C (activator 1) 1
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rfc1multiple interactionsEXP 6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RFC1 mRNA; RFC1 protein mutant form promotes the reaction [FOLR1 protein mutant form results in decreased abundance of Folic Acid]PMID:18926688 PMID:22206623
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