GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PARP1 | decreases expression | EXP | | 6480464 | CTD | Folic Acid results in decreased expression of PARP1 mRNA | PMID:36354958 | PARP1 | increases cleavage | EXP | | 6480464 | CTD | Folic Acid results in increased cleavage of PARP1 protein | PMID:16728583 | PARP1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PARP1 mRNA] | PMID:22206623 | PARP1 | multiple interactions | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | Folic Acid inhibits the reaction [Methotrexate results in increased cleavage of PARP1 protein]; Folic Acid inhibits the reaction [Nicotine results in decreased expression of PARP1 protein] | PMID:29972271 PMID:30502384 | |
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