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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317048
Species: Homo sapiens
RGD Object: Gene
Symbol: PAK4
Name: p21 (RAC1) activated kinase 4
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PAK4increases expressionISOPak4 (Mus musculus)6480464CTDFolic Acid results in increased expression of PAK4 mRNAPMID:25629700
PAK4multiple interactionsISOPak4 (Mus musculus)6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PAK4 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PAK4 genePMID:20938992 PMID:22206623
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