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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309472
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc46a1
Name: solute carrier family 46 member 1
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc46a1increases transportEXP 6480464CTDSLC46A1 protein results in increased transport of Folic AcidPMID:18174275
Slc46a1multiple interactionsEXP 6480464CTD[Folic Acid affects the susceptibility to Fructose] which affects the expression of SLC46A1 mRNA; Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]; Sulfobromophthalein inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]PMID:18174275 PMID:31612177
Slc46a1decreases expressionISOSLC46A1 (Homo sapiens)6480464CTDFolic Acid deficiency results in decreased expression of SLC46A1 mRNA; Folic Acid results in decreased expression of SLC46A1 mRNAPMID:17616776 PMID:20465997
Slc46a1increases transportISOSLC46A1 (Homo sapiens)6480464CTDSLC46A1 protein results in increased transport of Folic AcidPMID:17129779 PMID:17446347 PMID:17475902 PMID:19762432
Slc46a1increases uptakeISOSlc46a1 (Mus musculus)6480464CTDSLC46A1 protein results in increased uptake of Folic AcidPMID:21346251
Slc46a1multiple interactionsISOSlc46a1 (Mus musculus)6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SLC46A1 mRNAPMID:22206623
Slc46a1multiple interactionsISOSLC46A1 (Homo sapiens)6480464CTD4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]; 5-methyltetrahydrofolate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]; Leucovorin inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]; Methotrexate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]; Sulfobromophthalein inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]PMID:17475902
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