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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10671
Species: Mus musculus
RGD Object: Gene
Symbol: Gnmt
Name: glycine N-methyltransferase
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gnmtincreases expressionEXP 6480464CTDFolic Acid results in increased expression of GNMT mRNA; Folic Acid results in increased expression of GNMT proteinPMID:30920123
Gnmtaffects activityISOGnmt (Rattus norvegicus)6480464CTDFolic Acid affects the activity of GNMT proteinPMID:16632891
Gnmtmultiple interactionsISOGnmt (Rattus norvegicus)6480464CTDFolic Acid inhibits the reaction [Streptozocin results in increased activity of GNMT protein]PMID:16835399
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