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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10451
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:27452
Term: styrene
Definition: A vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species.
Chemical ID: MESH:D020058
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1affects metabolic processingEXP 6480464CTDCYP2E1 protein affects the metabolism of StyrenePMID:12746132
Cyp2e1increases metabolic processingEXP 6480464CTDCYP2E1 protein results in increased metabolism of StyrenePMID:24320693
Cyp2e1increases response to substanceEXP 6480464CTDCYP2E1 protein results in increased susceptibility to StyrenePMID:15110085
Cyp2e1multiple interactionsEXP 6480464CTD[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; [Ditiocarb co-treated with CYP2E1 gene mutant form] results in decreased metabolism of StyrenePMID:12746132 PMID:20470765
Cyp2e1affects metabolic processingISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 gene polymorphism affects the metabolism of Styrene; CYP2E1 protein affects the metabolism of StyrenePMID:12464798 PMID:12893075 PMID:20117323
Cyp2e1affects oxidationISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein affects the oxidation of StyrenePMID:16872732
Cyp2e1affects response to substanceISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 gene polymorphism affects the susceptibility to StyrenePMID:12604177 PMID:14751678 PMID:20117323
Cyp2e1decreases metabolic processingISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 gene polymorphism results in decreased metabolism of StyrenePMID:16125881
Cyp2e1increases expressionISOCYP2E1 (Homo sapiens)6480464CTDStyrene results in increased expression of CYP2E1 mRNAPMID:21030303
Cyp2e1increases expressionISOCyp2e1 (Rattus norvegicus)6480464CTDStyrene results in increased expression of CYP2E1 mRNA; Styrene results in increased expression of CYP2E1 proteinPMID:16418063 PMID:18202523
Cyp2e1increases oxidationISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased oxidation of StyrenePMID:1664256
Cyp2e1increases oxidationISOCyp2e1 (Rattus norvegicus)6480464CTDCYP2E1 protein results in increased oxidation of StyrenePMID:26463279
Cyp2e1increases response to substanceISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 gene polymorphism results in increased susceptibility to Styrene; CYP2E1 protein results in increased susceptibility to StyrenePMID:11535253 PMID:16872732
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTD[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; CYP2E1 results in increased metabolism of and results in increased susceptibility to Styrene; CYP2E1 results in increased metabolism of and results in increased susceptibility to Styrene analog; Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]; GSTM1 protein affects the reaction [CYP2E1 protein affects the metabolism of Styrene]; S-ethyl glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]; Smoke inhibits the reaction [CYP2E1 protein affects the metabolism of Styrene]PMID:12464798 PMID:16125881 PMID:16872732 PMID:20470765 PMID:22366341
Cyp2e1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTDgadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 protein]PMID:18202523
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