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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:27432
Term: alpha-linolenic acid
Definition: A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.
Chemical ID: MESH:D017962
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases activityISOGCLC (Homo sapiens)6480464CTDalpha-Linolenic Acid results in increased activity of GCLC proteinPMID:17092368
Gclcincreases expressionISOGCLC (Homo sapiens)6480464CTDalpha-Linolenic Acid results in increased expression of GCLC mRNAPMID:17092368
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