GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IL10 | decreases expression | ISO | Il10 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in decreased expression of IL10 mRNA | PMID:17056239 PMID:37009719 | IL10 | increases expression | ISO | Il10 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of IL10 protein | PMID:17038628 PMID:17412915 PMID:18279442 PMID:25445725 | IL10 | increases expression | ISO | Il10 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of IL10 mRNA; Carbon Tetrachloride results in increased expression of IL10 protein | PMID:14567445 PMID:15603720 | IL10 | increases secretion | ISO | Il10 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride results in increased secretion of IL10 protein | PMID:24973641 | IL10 | multiple interactions | ISO | Il10 (Mus musculus) | 6480464 | CTD | [2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide co-treated with Carbon Tetrachloride] results in increased expression of IL10 mRNA; Glatiramer Acetate promotes the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of ICAM1 mRNA]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of VCAM1 mRNA]; IL1RL1 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]; Lipids inhibits the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]; PLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]; PLAU protein affects the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]; PLAUR protein affects the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]; ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL10 protein] | PMID:16539848 PMID:17038628 PMID:17412915 PMID:18279442 PMID:24973641 PMID:25445725 PMID:26443840 | IL10 | multiple interactions | ISO | Il10 (Rattus norvegicus) | 6480464 | CTD | [Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL10 mRNA]; Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL10 mRNA]; IL10 protein affects the reaction [Carbon Tetrachloride results in increased expression of EGF mRNA]; IL10 protein affects the reaction [Carbon Tetrachloride results in increased expression of EGF protein]; IL10 protein affects the reaction [Carbon Tetrachloride results in increased expression of IGF1 protein]; IL10 protein affects the reaction [Carbon Tetrachloride results in increased expression of IGF1R protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Epoprostenol]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of AGT protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of EDN1 protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of GCG protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of HGF mRNA]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of HGF protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP2 mRNA]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP2 protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]; IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; IL10 protein promotes the reaction [Carbon Tetrachloride results in increased expression of FAS mRNA]; IL10 protein promotes the reaction [Carbon Tetrachloride results in increased expression of FAS protein]; IL10 protein promotes the reaction [Carbon Tetrachloride results in increased expression of FASLG mRNA]; IL10 protein promotes the reaction [Carbon Tetrachloride results in increased expression of FASLG protein]; oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL10 mRNA]; Resveratrol inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL10 mRNA] | PMID:12632514 PMID:12800242 PMID:14567445 PMID:14695773 PMID:15603720 PMID:15793858 PMID:16097045 PMID:16552806 PMID:16609999 PMID:16688825 PMID:17105443 PMID:18251166 PMID:37009719 | | ||||||||||||||||||||||
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