GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | increases phosphorylation | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased phosphorylation of AKT1 protein | PMID:27865854 PMID:31919559 PMID:35483553 PMID:37003405 | Akt1 | multiple interactions | EXP | | 6480464 | CTD | ANXA6 mRNA affects the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein]; fuzheng huayu inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein]; obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein] | PMID:27865854 PMID:35483553 PMID:37003405 | Akt1 | decreases phosphorylation | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in decreased phosphorylation of AKT1 protein | PMID:12388182 PMID:12891555 | Akt1 | increases expression | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of AKT1 mRNA; Carbon Tetrachloride results in increased expression of AKT1 protein | PMID:23374533 PMID:35236242 | Akt1 | increases phosphorylation | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in increased phosphorylation of AKT1 protein | PMID:18317400 PMID:22841775 PMID:23958495 | Akt1 | multiple interactions | ISO | Akt1 (Rattus norvegicus) | 6480464 | CTD | [Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA]; AKT1 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Cyclic GMP]; AKT1 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Nitric Oxide]; AKT1 protein inhibits the reaction [Carbon Tetrachloride results in decreased phosphorylation of NOS3 protein]; Carbon Tetrachloride results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 protein]; Folic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA]; Taurocholic Acid inhibits the reaction [Carbon Tetrachloride results in decreased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Taurocholic Acid inhibits the reaction [Carbon Tetrachloride results in decreased phosphorylation of AKT1 protein]] | PMID:12388182 PMID:12891555 PMID:18245901 PMID:18317400 PMID:23374533 PMID:35236242 | | ||||||||||||||||||||||
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