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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735204
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Panx1
Name: Pannexin 1
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Panx1increases expressionISOPanx1 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of PANX1 mRNAPMID:29987408
Panx1multiple interactionsISOPanx1 (Mus musculus)6480464CTD[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of PANX1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of ABCB1A mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of ABHD14B mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of AKR1E1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of AURKA mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of AVPR1A mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of CCL25 protein; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of CCND1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of CD59A mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of CD5L mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of CEACAM1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of CES3B mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of CMAH mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of COLEC12 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of COQ5 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of CRELD2 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of CYP2C40 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of CYP4A32 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of CYP8B1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of DEPP1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of DERL3 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of DNAJB11 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of DPY19L3 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of DRR1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of ENHO mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of ETFBKMT mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of FGL1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of H1F1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of IL1B protein; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of INHBC mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of LBP mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of LDHD mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of LRG1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of LY96 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of MIR292B mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of MIR297-1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of MIR466F-3 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of MIR5124A mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of MIR5125 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of MOCS1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of NR1D1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of NRP1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of OSGIN1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of PAPSS1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of PAQR9 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of PKHD1L1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of PSTPIP2 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of RMRP mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of RNU12 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of RPS24-PS3 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of RTP3 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of S100A9 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SAA4 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SCARNA6 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SDF2L1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SLC13A3 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SLC16A10 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SLC19A2 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SLC35E3 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SLCO2A1 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SNORA34 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SNORA69 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SNORA75 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SNORD118 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SNORD3A mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of SNORD93 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of TFF3 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of THEM7 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of TIMP2 protein; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of TMEM19 mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of TNF protein; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of TUBA4A mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of VPS33B mRNA; [PANX1 protein co-treated with Carbon Tetrachloride] affects the phosphorylation of RELA protein; PANX1 protein affects the reaction [Carbon Tetrachloride results in decreased expression of ELOVL3 mRNA]; PANX1 protein affects the reaction [Carbon Tetrachloride results in decreased expression of OAT mRNA]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of CASP1 mRNA]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of CCL1 protein]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of CLEC7A mRNA]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of GPNMB mRNA]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL2 protein]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of LOXL2 mRNA]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of MKI67 mRNA]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of PYCARD mRNA]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of TNFRSF1A protein]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of TNFRSF1B protein]; PANX1 protein affects the reaction [Carbon Tetrachloride results in increased expression of XCL1 protein]PMID:29987408 PMID:30517762
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