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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733705
Species: Homo sapiens
RGD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CTNNB1increases expressionISOCtnnb1 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of CTNNB1 mRNA; Carbon Tetrachloride results in increased expression of CTNNB1 proteinPMID:27477297 PMID:29535048 PMID:33640489 PMID:35411647
CTNNB1multiple interactionsISOCtnnb1 (Mus musculus)6480464CTDCarbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of CTNNB1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]PMID:27477297 PMID:33640489 PMID:35411647
CTNNB1multiple interactionsISOCtnnb1 (Rattus norvegicus)6480464CTD1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of CTNNB1 protein]; [Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of CTNNB1 proteinPMID:35872049
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