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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730855
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD1
Name: superoxide dismutase 1
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD1decreases activityISOSod1 (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased activity of SOD1 proteinPMID:21095217 PMID:22902988 PMID:37573684
SOD1decreases activityISOSod1 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in decreased activity of SOD1 proteinPMID:17030452 PMID:30676168
SOD1decreases expressionISOSod1 (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased expression of SOD1 mRNA; Carbon Tetrachloride results in decreased expression of SOD1 proteinPMID:21725986 PMID:37894611
SOD1decreases expressionISOSod1 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in decreased expression of SOD1 mRNAPMID:24293383 PMID:30578595
SOD1increases activityISOSod1 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased activity of SOD1 proteinPMID:19747501
SOD1increases expressionISOSod1 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased expression of SOD1 mRNA; Carbon Tetrachloride results in increased expression of SOD1 proteinPMID:16644059 PMID:17877538
SOD1multiple interactionsISOSod1 (Mus musculus)6480464CTDalisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Berberine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; gentian root extract inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD1 protein]; Luteolin inhibits the reaction [Carbon Tetrachloride results in increased activity of SOD1 protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; salecan inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD1 mRNA]PMID:19747501 PMID:21095217 PMID:21725986 PMID:22902988 PMID:37573684 PMID:37894611
SOD1multiple interactionsISOSod1 (Rattus norvegicus)6480464CTDAscorbic Acid inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD1 mRNA]; Oils, Volatile inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD1 mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]PMID:17030452 PMID:24293383 PMID:30578595 PMID:30676168
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