GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1h4 | decreases expression | EXP | | 15042868 | RGD | Carbon Tetrachloride decreases expression of Nr1h4 mRNA in rat liver | | Nr1h4 | decreases expression | EXP | | 6480464 | CTD | Carbon Tetrachloride results in decreased expression of NR1H4 mRNA | PMID:16644059 PMID:32380060 | Nr1h4 | multiple interactions | EXP | | 6480464 | CTD | 1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased expression of NR1H4 protein]; [Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased expression of NR1H4 protein | PMID:35872049 | Nr1h4 | decreases expression | ISO | Nr1h4 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride results in decreased expression of NR1H4 mRNA | PMID:27339419 PMID:31919559 PMID:37894611 | Nr1h4 | increases expression | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of NR1H4 mRNA | PMID:11566570 | Nr1h4 | increases response to substance | ISO | Nr1h4 (Mus musculus) | 6480464 | CTD | NR1H4 gene mutant form results in increased susceptibility to Carbon Tetrachloride | PMID:28505368 | Nr1h4 | multiple interactions | ISO | Nr1h4 (Mus musculus) | 6480464 | CTD | ABCB11 inhibits the reaction [NR1H4 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]]; ABCB11 inhibits the reaction [NR1H4 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 mRNA]]; ABCB11 inhibits the reaction [NR1H4 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]]; gentian root extract inhibits the reaction [Carbon Tetrachloride results in decreased expression of NR1H4 mRNA]; NR1H4 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]; NR1H4 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 mRNA]; NR1H4 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA] | PMID:28505368 PMID:37894611 | | ||||||||||||||||||||||
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