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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628656
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Has3
Name: hyaluronan synthase 3
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Has3affects response to substanceISOHas3 (Mus musculus)6480464CTDHAS3 protein affects the susceptibility to Carbon TetrachloridePMID:27042213
Has3increases expressionISOHas3 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of HAS3 mRNAPMID:27042213
Has3multiple interactionsISOHas3 (Mus musculus)6480464CTD[HAS3 protein affects the susceptibility to Carbon Tetrachloride] which affects the abundance of Hyaluronic Acid; [HAS3 protein affects the susceptibility to Carbon Tetrachloride] which affects the expression of MMP13 protein; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased abundance of Hyaluronic Acid]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of CCN2 mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of CXCL1 mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of CXCL1 protein]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of CXCL10 mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of CXCL10 protein]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of HAS1 mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of HAS2 mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of ITGAM mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP13 mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of SERPINH1 mRNA]; HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]PMID:27042213
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