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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit3increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of DDIT3 mRNA; Carbon Tetrachloride results in increased expression of DDIT3 proteinPMID:15056808 PMID:19911120 PMID:25827057 PMID:27339419 PMID:31919559
Ddit3multiple interactionsEXP 6480464CTD1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of DDIT3 mRNA]PMID:25827057
Ddit3increases expressionISODdit3 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased expression of DDIT3 mRNAPMID:17522070 PMID:31150632
Ddit3multiple interactionsISODdit3 (Rattus norvegicus)6480464CTD[Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of DDIT3 mRNA; schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of DDIT3 mRNA]PMID:20097184 PMID:31150632
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