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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621635
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bak1
Name: BCL2-antagonist/killer 1
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bak1multiple interactionsEXP 6480464CTD[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BAK1 mRNAPMID:16610055
Bak1increases expressionISOBak1 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of BAK1 proteinPMID:23279844 PMID:25432964
Bak1multiple interactionsISOBak1 (Mus musculus)6480464CTDDinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]]; Flavonoids inhibits the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]; Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]; PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]; SC 560 promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]PMID:23279844 PMID:25432964
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