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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3283
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdgfb
Name: platelet derived growth factor subunit B
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdgfbincreases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of PDGFB proteinPMID:12930639 PMID:14761280 PMID:18006644
Pdgfbmultiple interactionsEXP 6480464CTDCarbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]PMID:12930639 PMID:14761280 PMID:16097048 PMID:18006644
Pdgfbincreases expressionISOPdgfb (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of PDGFB mRNA; Carbon Tetrachloride results in increased expression of PDGFB proteinPMID:17341687 PMID:32956689
Pdgfbmultiple interactionsISOPdgfb (Mus musculus)6480464CTDS1PR2 protein affects the reaction [Carbon Tetrachloride results in increased expression of PDGFB mRNA]; Silymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]; Vildagliptin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]PMID:17341687 PMID:32956689
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