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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2479
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp4a2
Name: cytochrome P450, family 4, subfamily a, polypeptide 2
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of CYP4A2 mRNA, Carbon Tetrachloride results in increased expression of CYP4A2 protein

PMID:17606319, PMID:24582681, PMID:31150632
multiple interactionsEXP 6480464CTDDrugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP4A2 mRNA], Silymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP4A2 mRNA]

PMID:24582681
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.