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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2decreases activityEXP 6480464CTDCarbon Tetrachloride results in decreased activity of ABCC2 proteinPMID:16899240
Abcc2decreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of ABCC2 proteinPMID:12642476 PMID:16899240 PMID:17544377
Abcc2multiple interactionsEXP 6480464CTD[Carbon Tetrachloride co-treated with Valproic Acid] affects the expression of ABCC2 mRNAPMID:17617793
Abcc2increases expressionISOAbcc2 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of ABCC2 mRNA; Carbon Tetrachloride results in increased expression of ABCC2 proteinPMID:15496496 PMID:16177239 PMID:25747392 PMID:29964319
Abcc2multiple interactionsISOAbcc2 (Mus musculus)6480464CTDalisol B 23-acetate promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC2 mRNA]; Chenodeoxycholic Acid promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC2 mRNA]; ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC2 protein]; Tretinoin inhibits the reaction [Carbon Tetrachloride results in increased expression of ABCC2 protein]; Tretinoin inhibits the reaction [ginsenoside Rg1 promotes the reaction [Carbon Tetrachloride results in increased expression of ABCC2 protein]]PMID:25747392 PMID:29964319
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