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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2326
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cebpa
Name: CCAAT/enhancer binding protein alpha
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cebpadecreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of CEBPA mRNAPMID:31150632
Cebpadecreases expressionISOCebpa (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased expression of CEBPA mRNA; Carbon Tetrachloride results in decreased expression of CEBPA proteinPMID:17484886 PMID:20438794 PMID:25432964 PMID:27339419 PMID:31919559
Cebpamultiple interactionsISOCebpa (Mus musculus)6480464CTDDinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CEBPA protein]]; epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CEBPA protein]; PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CEBPA protein]; SC 560 promotes the reaction [Carbon Tetrachloride results in decreased expression of CEBPA protein]PMID:20438794 PMID:25432964
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