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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2096
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alox5
Name: arachidonate 5-lipoxygenase
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox5increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of ALOX5 proteinPMID:16033810
Alox5multiple interactionsEXP 6480464CTD2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ALOX5 protein]PMID:16033810
Alox5increases expressionISOAlox5 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of ALOX5 proteinPMID:25432964
Alox5multiple interactionsISOAlox5 (Mus musculus)6480464CTDPTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of ALOX5 protein]; SC 560 promotes the reaction [Carbon Tetrachloride results in increased expression of ALOX5 protein]PMID:25432964
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