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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2065
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Afp
Name: alpha-fetoprotein
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Afpdecreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of AFP mRNAPMID:31150632
Afpincreases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of AFP proteinPMID:16965562 PMID:61145
Afpmultiple interactionsEXP 6480464CTD1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of AFP protein; [Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein; [Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein; Aminoacetonitrile inhibits the reaction [Carbon Tetrachloride results in increased expression of AFP protein]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; N,N'-diphenyl-4-phenylenediamine inhibits the reaction [Carbon Tetrachloride results in increased expression of AFP protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of AFP mRNA]; Silymarin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]PMID:11813887 PMID:28693887 PMID:28935427 PMID:29923357 PMID:31150632 PMID:61145
Afpincreases expressionISOAfp (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of AFP mRNA; Carbon Tetrachloride results in increased expression of AFP proteinPMID:16965562 PMID:17668883 PMID:23288052 PMID:27339419 PMID:29987408 PMID:31919559 PMID:70250
Afpmultiple interactionsISOAfp (Mus musculus)6480464CTDDiethylnitrosamine promotes the reaction [Carbon Tetrachloride results in increased expression of AFP mRNA]PMID:23288052
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