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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605125
Species: Homo sapiens
RGD Object: Gene
Symbol: ERN1
Name: endoplasmic reticulum to nucleus signaling 1
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ERN1increases activityISOErn1 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased activity of ERN1 proteinPMID:25858767
ERN1increases expressionISOErn1 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased expression of ERN1 mRNAPMID:31150632
ERN1increases phosphorylationISOErn1 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased phosphorylation of ERN1 proteinPMID:25827057 PMID:30538632
ERN1multiple interactionsISOErn1 (Mus musculus)6480464CTD1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of ERN1 protein]PMID:25827057
ERN1multiple interactionsISOErn1 (Rattus norvegicus)6480464CTDschizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ERN1 mRNA]PMID:31150632
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