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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318106
Species: Homo sapiens
RGD Object: Gene
Symbol: SIRT3
Name: sirtuin 3
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SIRT3decreases expressionISOSirt3 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in decreased expression of SIRT3 mRNAPMID:31150632
SIRT3decreases expressionISOSirt3 (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased expression of SIRT3 mRNA; Carbon Tetrachloride results in decreased expression of SIRT3 proteinPMID:27339419 PMID:30368983 PMID:31919559
SIRT3decreases response to substanceISOSirt3 (Mus musculus)6480464CTDSIRT3 protein results in decreased susceptibility to Carbon TetrachloridePMID:30368983
SIRT3multiple interactionsISOSirt3 (Rattus norvegicus)6480464CTD1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased expression of SIRT3 protein]; [Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in decreased expression of SIRT3 protein; schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SIRT3 mRNA]PMID:31150632 PMID:35872049
SIRT3multiple interactionsISOSirt3 (Mus musculus)6480464CTD[mangostin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion of SIRT3 protein; SIRT3 protein affects the reaction [Carbon Tetrachloride results in decreased activity of SOD2 protein]; SIRT3 protein affects the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; SIRT3 protein affects the reaction [Carbon Tetrachloride results in increased expression of GPT protein]PMID:30368983 PMID:30502394
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