Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	11161
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Proc
Name:	protein C

Acc ID:	CHEBI:27385
Term:	tetrachloromethane
Definition:	A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID:	MESH:D002251

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Proc	decreases expression	EXP		6480464	CTD	Carbon Tetrachloride results in decreased expression of PROC mRNA	PMID:31919559
Proc	decreases expression	ISO	Proc (Rattus norvegicus)	6480464	CTD	Carbon Tetrachloride results in decreased expression of PROC mRNA	PMID:30690589 PMID:31150632
Proc	increases methylation	ISO	Proc (Rattus norvegicus)	6480464	CTD	Carbon Tetrachloride results in increased methylation of PROC promoter	PMID:30690589
Proc	multiple interactions	ISO	Proc (Rattus norvegicus)	6480464	CTD	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PROC mRNA]	PMID:31150632

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