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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11068
Species: Mus musculus
RGD Object: Gene
Symbol: Pdgfb
Name: platelet derived growth factor, B polypeptide
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdgfbincreases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of PDGFB mRNA; Carbon Tetrachloride results in increased expression of PDGFB proteinPMID:17341687 PMID:32956689 PMID:38042390
Pdgfbmultiple interactionsEXP 6480464CTDfuzheng huayu inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB mRNA]; S1PR2 protein affects the reaction [Carbon Tetrachloride results in increased expression of PDGFB mRNA]; Silymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]; tianhuang inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB mRNA]; Vildagliptin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]PMID:17341687 PMID:32956689 PMID:38042390
Pdgfbincreases expressionISOPdgfb (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased expression of PDGFB proteinPMID:12930639 PMID:14761280 PMID:18006644
Pdgfbmultiple interactionsISOPdgfb (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]PMID:12930639 PMID:14761280 PMID:16097048 PMID:18006644
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