Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10789
Species: Mus musculus
RGD Object: Gene
Symbol: Il1a
Name: interleukin 1 alpha
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1adecreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of IL1A mRNAPMID:31919559
Il1aincreases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of IL1A mRNA; Carbon Tetrachloride results in increased expression of IL1A proteinPMID:18395288 PMID:30301768 PMID:37894611
Il1amultiple interactionsEXP 6480464CTDCD44 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL1A mRNA]; gentian root extract inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1A protein]; MGLL protein affects the reaction [Carbon Tetrachloride results in increased expression of IL1A mRNA]PMID:18395288 PMID:30301768 PMID:37894611
Il1aincreases activityISOIl1a (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased activity of IL1A proteinPMID:25858767
Il1aincreases expressionISOIl1a (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased expression of IL1A proteinPMID:17904177
Go Back to source page   Continue to Ontology report