Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	10127
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Ahr
Name:	aryl-hydrocarbon receptor

Acc ID:	CHEBI:27385
Term:	tetrachloromethane
Definition:	A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID:	MESH:D002251

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Ahr	decreases expression	EXP		6480464	CTD	Carbon Tetrachloride results in decreased expression of AHR mRNA	PMID:27339419
Ahr	multiple interactions	EXP		6480464	CTD	Carbon Tetrachloride affects the localization of and results in increased activity of AHR protein; IDO2 gene mutant form inhibits the reaction [Carbon Tetrachloride affects the localization of and results in increased activity of AHR protein]	PMID:32289347
Ahr	decreases expression	ISO	Ahr (Rattus norvegicus)	6480464	CTD	Carbon Tetrachloride results in decreased expression of AHR mRNA	PMID:31150632
Ahr	increases expression	ISO	Ahr (Rattus norvegicus)	6480464	CTD	Carbon Tetrachloride results in increased expression of AHR mRNA	PMID:31168027 PMID:32380060
Ahr	multiple interactions	ISO	Ahr (Rattus norvegicus)	6480464	CTD	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of AHR mRNA]	PMID:31150632

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