GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ABCB1 | affects binding | EXP | | 6480464 | CTD | Vinblastine binds to ABCB1 protein | PMID:23976943 | ABCB1 | affects uptake | EXP | | 6480464 | CTD | ABCB1 protein affects the uptake of Vinblastine | PMID:15640379 | ABCB1 | decreases response to substance | EXP | | 6480464 | CTD | ABCB1 protein results in decreased susceptibility to Vinblastine | PMID:11355955 PMID:15725475 PMID:17284363 PMID:26689174 PMID:8917702 PMID:9148857 | ABCB1 | increases activity | EXP | | 6480464 | CTD | Vinblastine results in increased activity of ABCB1 protein mutant form | PMID:12711602 | ABCB1 | increases expression | EXP | | 6480464 | CTD | Vinblastine results in increased expression of ABCB1 protein | PMID:20041327 | ABCB1 | increases secretion | EXP | | 6480464 | CTD | ABCB1 protein results in increased secretion of Vinblastine | PMID:12235267 | ABCB1 | increases transport | EXP | | 6480464 | CTD | ABCB1 protein results in increased transport of Vinblastine | PMID:12708479 PMID:16221533 PMID:23976943 | ABCB1 | multiple interactions | EXP | | 6480464 | CTD | [Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]] which results in decreased susceptibility to Vinblastine; [Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Vinblastine; [Glycyrrhetinic Acid affects the activity of ABCB1 protein] which affects the susceptibility to Vinblastine; [sodium arsenite results in increased expression of ABCB1 protein] which results in decreased susceptibility to Vinblastine; [Vinblastine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; Amiodarone inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; cnidiadin inhibits the reaction [ABCB1 protein results in increased export of Vinblastine]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Diazinon affects the reaction [ABCB1 protein results in increased transport of Vinblastine]; Erythromycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; NR1I2 protein promotes the reaction [Vinblastine results in increased expression of ABCB1 protein]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Sesquiterpenes analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein affects the uptake of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; Vinblastine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form] | PMID:12235267 PMID:12708479 PMID:12711602 PMID:15466210 PMID:15640379 PMID:15824923 PMID:16221533 PMID:18204840 PMID:1967174 PMID:20041327 PMID:23976943 PMID:26689174 | ABCB1 | decreases response to substance | ISO | Abcb1a (Rattus norvegicus) | 6480464 | CTD | ABCB1 protein results in decreased susceptibility to Vinblastine | PMID:11455017 | ABCB1 | increases secretion | ISO | Abcb1a (Mus musculus) | 6480464 | CTD | ABCB1A protein results in increased secretion of Vinblastine | PMID:12235267 | | ||||||||||||||||||||||
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