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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736832
Species: Homo sapiens
RGD Object: Gene
Symbol: EGF
Name: epidermal growth factor
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGFincreases uptakeEXP 6480464CTDEGF protein results in increased uptake of ZincPMID:1502195
EGFmultiple interactionsEXP 6480464CTDMitomycin inhibits the reaction [EGF protein results in increased uptake of Zinc]PMID:1502195
EGFincreases expressionISOEgf (Rattus norvegicus)6480464CTDZinc deficiency results in increased expression of EGF mRNAPMID:19111725
EGFincreases importISOEgf (Mus musculus)6480464CTDEGF protein results in increased import of ZincPMID:16443356
EGFmultiple interactionsISOEgf (Rattus norvegicus)6480464CTDZinc inhibits the reaction [Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein]]PMID:12947092
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