GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | APP | affects binding | EXP | | 6480464 | CTD | APP protein binds to Zinc; APP protein modified form binds to Zinc; Zinc binds to APP protein; Zinc binds to APP protein alternative form | PMID:15699049 PMID:16266835 PMID:16404590 PMID:17119284 PMID:24855651 | APP | increases degradation | EXP | | 6480464 | CTD | Zinc results in increased degradation of APP protein modified form | PMID:18068270 | APP | increases secretion | EXP | | 6480464 | CTD | Zinc results in increased secretion of APP protein alternative form | PMID:16648635 | APP | multiple interactions | EXP | | 6480464 | CTD | Clioquinol inhibits the reaction [Zinc results in increased secretion of APP protein alternative form]; Zinc binds to and affects the folding of APP protein; Zinc inhibits the reaction [APP protein modified form results in increased reduction of Copper]; Zinc inhibits the reaction [APP protein results in increased reduction of Copper]; Zinc promotes the reaction [APP protein binds to APLP1 protein]; Zinc promotes the reaction [APP protein binds to APLP2 protein]; Zinc promotes the reaction [APP protein binds to APP protein]; Zinc promotes the reaction [Heparin binds to APP protein] | PMID:12572668 PMID:16325427 PMID:16648635 PMID:24855651 PMID:25835329 | APP | increases expression | ISO | App (Rattus norvegicus) | 6480464 | CTD | Zinc deficiency results in increased expression of APP mRNA | PMID:19111725 | APP | multiple interactions | ISO | App (Rattus norvegicus) | 6480464 | CTD | [Zinc promotes the reaction [APP protein binds to APP protein]] which affects the transport of Potassium | PMID:16674922 | APP | multiple interactions | ISO | App (Mus musculus) | 6480464 | CTD | [APP protein co-treated with Zinc] results in increased degradation of GPC1 protein modified form | PMID:15677459 | |
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