GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | VCAM1 | decreases expression | EXP | | 6480464 | CTD | Zinc results in decreased expression of VCAM1 protein | PMID:20427734 | VCAM1 | multiple interactions | EXP | | 6480464 | CTD | Zinc inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of VCAM1 protein]; Zinc inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of VCAM1 protein] | PMID:21035309 | VCAM1 | increases expression | ISO | Vcam1 (Rattus norvegicus) | 6480464 | CTD | Zinc deficiency results in increased expression of VCAM1 | PMID:20128680 | VCAM1 | multiple interactions | ISO | Vcam1 (Mus musculus) | 6480464 | CTD | [LDLR gene mutant form results in increased susceptibility to Zinc deficiency] which results in increased expression of VCAM1 mRNA; [LDLR gene mutant form results in increased susceptibility to Zinc deficiency] which results in increased expression of VCAM1 protein; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of VCAM1 mRNA; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of VCAM1 mRNA]; Zinc deficiency promotes the reaction [Dietary Fats results in increased expression of VCAM1 protein]; Zinc inhibits the reaction [Dietary Fats results in increased expression of VCAM1 protein] | PMID:16140885 PMID:23503329 PMID:27370414 | |
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