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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70488
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tfrc
Name: transferrin receptor
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfrcincreases expressionISOTfrc (Mus musculus)6480464CTDZinc deficiency results in increased expression of TFRC mRNA; Zinc deficiency results in increased expression of TFRC proteinPMID:18073202
Tfrcmultiple interactionsISOTfrc (Mus musculus)6480464CTD[Ascorbic Acid co-treated with CAT protein] inhibits the reaction [Zinc deficiency results in increased expression of TFRC protein]; [Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC mRNA; [Zinc deficiency results in increased abundance of Iron] which results in increased expression of TFRC protein; Acetylcysteine inhibits the reaction [Zinc deficiency results in increased expression of TFRC protein]; etiron promotes the reaction [Zinc deficiency results in increased expression of TFRC protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide promotes the reaction [Zinc deficiency results in increased expression of TFRC protein]PMID:18073202
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