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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69147
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP9
Name: caspase 9
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP9multiple interactionsEXP 6480464CTD[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein; [PCI 5002 co-treated with Zinc] results in increased expression of CASP9 mRNA; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein]PMID:18593933 PMID:29115570
CASP9decreases expressionISOCasp9 (Rattus norvegicus)6480464CTDZinc results in decreased expression of CASP9 proteinPMID:32060784
CASP9multiple interactionsISOCasp9 (Rattus norvegicus)6480464CTD[Calcium co-treated with Zinc] affects the reaction [monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in increased expression of CASP9 mRNA]]; Paraquat promotes the reaction [Zinc results in decreased expression of CASP9 protein]; Zinc affects the reaction [sodium arsenite results in increased expression of CASP9 mRNA]; Zinc promotes the reaction [Paraquat results in decreased expression of CASP9 protein]PMID:24184500 PMID:32060784
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