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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350530
Species: Homo sapiens
RGD Object: Gene
Symbol: SRC
Name: SRC proto-oncogene, non-receptor tyrosine kinase
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SRCdecreases activityEXP 6480464CTDZinc results in decreased activity of SRC proteinPMID:16410015
SRCincreases expressionEXP 6480464CTDZinc deficiency results in increased expression of SRC mRNAPMID:18356318
SRCincreases phosphorylationEXP 6480464CTDZinc results in increased phosphorylation of SRC proteinPMID:12915106 PMID:12972402 PMID:15980035
SRCmultiple interactionsEXP 6480464CTDN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased phosphorylation of SRC protein]PMID:12972402
SRCincreases phosphorylationISOSrc (Mus musculus)6480464CTDZinc deficiency results in increased phosphorylation of SRC proteinPMID:20101602
SRCmultiple interactionsISOSrc (Mus musculus)6480464CTDZinc promotes the reaction [EGFR protein binds to SRC protein]; Zinc results in increased phosphorylation of and results in increased activity of SRC proteinPMID:11983694
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