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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308236
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc39a8
Name: solute carrier family 39 member 8
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc39a8decreases expressionEXP 6480464CTDZinc deficiency results in decreased expression of SLC39A8 mRNAPMID:20859692
Slc39a8increases expressionEXP 6480464CTDZinc results in increased expression of SLC39A8 proteinPMID:22898811
Slc39a8increases importEXP 6480464CTDSLC39A8 protein results in increased import of ZincPMID:22898811
Slc39a8multiple interactionsEXP 6480464CTDIron inhibits the reaction [SLC39A8 protein results in increased import of Zinc]; Zinc inhibits the reaction [SLC39A8 protein results in increased import of Iron]PMID:22898811
Slc39a8decreases expressionISOSlc39a8 (Mus musculus)6480464CTDZinc results in decreased expression of SLC39A8 mRNAPMID:17085522
Slc39a8increases transportISOSLC39A8 (Homo sapiens)6480464CTDSLC39A8 protein results in increased transport of ZincPMID:18326752
Slc39a8increases uptakeISOSlc39a8 (Mus musculus)6480464CTDSLC39A8 protein results in increased uptake of ZincPMID:27956349
Slc39a8multiple interactionsISOSLC39A8 (Homo sapiens)6480464CTD[TNF protein results in increased expression of SLC39A8 protein] which results in increased import of ZincPMID:18390834
Slc39a8multiple interactionsISOSlc39a8 (Mus musculus)6480464CTDBicarbonates affects the reaction [SLC39A8 protein results in increased uptake of Zinc]; Cadmium inhibits the reaction [SLC39A8 protein results in increased uptake of Zinc]; Cobalt inhibits the reaction [SLC39A8 protein results in increased uptake of Zinc]; Copper inhibits the reaction [SLC39A8 protein results in increased uptake of Zinc]; Iron inhibits the reaction [SLC39A8 protein results in increased uptake of Zinc]; Nickel inhibits the reaction [SLC39A8 protein results in increased uptake of Zinc]PMID:27956349
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