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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp27b1
Name: cytochrome P450, family 27, subfamily b, polypeptide 1
Acc ID: CHEBI:27300
Term: vitamin D
Definition: Any member of a group of fat-soluble hydroxy seco-steroids that exhibit biological activity against vitamin D deficiency. Vitamin D can be obtained from sun exposure, food and supplements and is biologically inactive and converted into the biologically active calcitriol via double hydroxylation in the body.
Chemical ID: MESH:D014807
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp27b1increases expressionEXP 6480464CTDVitamin D deficiency results in increased expression of CYP27B1 proteinPMID:8410379
Cyp27b1multiple interactionsISOCyp27b1 (Mus musculus)6480464CTD[Ethanol co-treated with Vitamin D] results in decreased expression of CYP27B1 mRNAPMID:22892342
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